Actively Recruiting
Amplitude Titration to Improve ECT Clinical Outcomes
Led by University of New Mexico · Updated on 2026-01-26
50
Participants Needed
1
Research Sites
224 weeks
Total Duration
On this page
Sponsors
U
University of New Mexico
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode placement switch at V2). H2: Individualized amplitude arm will have improved cognitive outcomes (DKEFS-Verbal Fluency
CONDITIONS
Official Title
Amplitude Titration to Improve ECT Clinical Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of major depressive disorder or bipolar II
- Clinical indications for electroconvulsive therapy with right unilateral electrode placement
You will not qualify if you...
- Defined neurological or neurodegenerative disorder such as traumatic brain injury, epilepsy, or Alzheimer's disease
- Other psychiatric conditions like schizophrenia or bipolar I disorder
- Current drug or alcohol use disorder, except for nicotine
- Contraindications to MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of New Mexico Health Science Center
Albuquerque, New Mexico, United States, 87110
Actively Recruiting
Research Team
C
Chris Abbott, MD
CONTACT
M
Megan Lloyd, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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