Study on Protein Response and Metabolism in Adults with Chronic Intestinal Failure Receiving Home Parenteral Nutrition

What this Trial Is About

Researchers are studying patients with chronic intestinal failure CIF who receive home parenteral nutrition to better understand their actual protein needs. This study aims to improve clinical care by analyzing protein metabolism and anabolic responses to intravenous amino acid administration. It also investigates short-chain fatty acid metabolism and gut microbiota function to provide comprehensive insights into the metabolic phenotype of these patients. Participants receive intravenous amino acids while on home parenteral nutrition. This treatment is used to assess their anabolic response and protein kinetics, helping to refine and personalize nutritional mixtures. The study is prospective and observational, focusing on how patients metabolize protein after amino acid infusion. During the study, researchers measure whole-body protein synthesis rates before and immediately after amino acid infusion, within one day. Patient evaluations include metabolic assessments to support optimization of their nutrition therapy. The total duration and specific visit schedules are based on the timing of these measurements and treatment administration.

Anabolic Response To Intravenous Amino Acids In Chronic Intestinal Failure Patients