Actively Recruiting
Anabolic Response To Protein And Assessment Of Metabolic Phenotype In Patients With Home Parenteral Nutrition And Chronic Intestinal Failure
Led by Institute of Oncology Ljubljana · Updated on 2026-02-20
40
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with chronic intestinal failure (CIF) who receive home parenteral nutrition to better understand their actual protein needs. This study aims to improve clinical care by analyzing protein metabolism and anabolic responses to intravenous amino acid administration. It also investigates short-chain fatty acid metabolism and gut microbiota function to provide comprehensive insights into the metabolic phenotype of these patients. Participants receive intravenous amino acids while on home parenteral nutrition. This treatment is used to assess their anabolic response and protein kinetics, helping to refine and personalize nutritional mixtures. The study is prospective and observational, focusing on how patients metabolize protein after amino acid infusion. During the study, researchers measure whole-body protein synthesis rates before and immediately after amino acid infusion, within one day. Patient evaluations include metabolic assessments to support optimization of their nutrition therapy. The total duration and specific visit schedules are based on the timing of these measurements and treatment administration.
CONDITIONS
Brief Title
Anabolic Response To Intravenous Amino Acids In Chronic Intestinal Failure Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single administration with assessments before and immediately after infusion (within 1 day)
Participants receive intravenous amino acid administration to assess anabolic response and metabolic phenotype.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Institute of Oncology Ljubljana
Ljubljana, Slovenia, 1000
Actively Recruiting
Research Team
K
Klavdija Korošec
N
Neža Gros
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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