Actively Recruiting
Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy
Led by Hospices Civils de Lyon · Updated on 2026-01-15
30
Participants Needed
1
Research Sites
63 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Analgesia Nociception Index (ANI) reflects the balance between sympathetic and parasympathetic tone. It is based on a specific interpretation of the R-R interval variation. During fluid removal by net ultrafiltration in patients with fluid overload and continuous renal replacement therapy, some data suggest that haemodynamic variation could be induced by the autonomic nervous system. The study aims to investigate ANI variations in this context and their association with the haemodynamic variations observed.
CONDITIONS
Official Title
Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Receiving continuous renal replacement therapy in an intensive care unit
- Starting net ultrafiltration based on department protocol or EARLYDRY study criteria
- Fluid overload greater than 5% or presence of peripheral oedema
- Noradrenaline equivalent dose less than 0.5 µg/kg/min
- No peripheral hypoperfusion
- Invasive blood pressure monitoring is in place
- Central venous line located in superior vena cava territory
- Regular sinus heart rhythm
- Patient is awake or sedation scale score is greater than -3 (Richmond Agitation and Sedation Scale)
You will not qualify if you...
- Currently receiving inotropes
- Currently receiving beta blockers
- Currently receiving alpha-2 agonists
- History of dysautonomia
- Pregnant or breastfeeding women
- Using mechanical circulatory assistance
- Patient opposes participation
- Adults under legal protection
- Persons deprived of liberty by judicial or administrative decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Département d'anesthésie-réanimation Hôpital cardiologique Louis Pradel
Bron, France, 69500
Actively Recruiting
Research Team
M
Martin RUSTE, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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