Comparing Goal-Directed Analgesia Using ANI Monitoring With Standard Analgesia During General Anesthesia For Adults Undergoing Maxillofacial Orthognathic Surgery To Improve Postoperative Recovery Quality

What this Trial Is About

Researchers are studying whether using the AnalgesiaNociception Index ANI to guide pain relief during surgery can improve recovery quality after maxillofacial jaw surgery. This trial compares goal-directed analgesia guided by ANI monitoring to standard pain management during general anesthesia. The study is a prospective, randomized controlled trial led by Seoul National University Hospital. Participants will undergo maxillary, mandibular, or bimaxillary surgery under general anesthesia. In the experimental group, remifentanil infusion for pain relief is adjusted based on ANI monitoring, a device measuring pain response. In the control group, remifentanil dosing is managed according to the clinicians judgment without ANI guidance. Both groups receive anesthesia and pain management during surgery, with the study assessing differences in recovery. During the study, researchers will assess participants postoperative recovery quality using the QoR-15K score 24 hours after surgery. They will also measure patient satisfaction, pain levels, opioid and non-opioid drug use during and after surgery, anesthesia details, blood pressure stability, blood loss, fluid administration, extubation time, and side effects like nausea and opioid-related symptoms. The total study duration includes surgery and follow-up assessments within the first 24 hours post-surgery.

Analgesia Nociception Index in Orthognathic Surgery