Validity and Internal Consistency of the New Knee Society Knee Scoring System.
Sharon E Culliton, Dianne M Bryant, Steven J MacDonald...
https://pubmed.ncbi.nlm.nih.gov/29529620Actively Recruiting
Phase 3
Age: 18Years - 80Years
All Genders
ID06740214
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty: a Randomized Controlled Trial
Led by The University of Hong Kong · Updated on 2025-11-24
177
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Total knee arthroplasty (TKA) is a common surgery for severe osteoarthritis when other treatments do not work. However, many patients experience significant pain after surgery, which can slow recovery and increase opioid use. Researchers are studying different doses of liposomal bupivacaine in the adductor canal block, a pain relief technique, to see how it affects pain and opioid use after robotic-assisted TKA. This is a randomized controlled trial sponsored by The University of Hong Kong. Participants will receive one of three treatments during surgery: an adductor canal block with standard bupivacaine, a combination of liposomal and standard bupivacaine, or liposomal bupivacaine alone in different doses. The study will compare the effects of these doses on pain relief and opioid consumption. The trial uses a triple-blind method and includes detailed monitoring of drug levels, pain scores, and recovery measures. During the study, participants will have their pain levels measured frequently for up to 7 days after surgery, along with assessments of knee function, opioid side effects, and quality of recovery. Blood samples will be taken to check bupivacaine levels. Long-term outcomes such as chronic pain, knee function, and quality of life will be evaluated at 6 weeks, 3 months, and 6 months post-surgery. The primary outcome is the overall pain score at rest during the first 48 hours after surgery.
CONDITIONS
Brief Title
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- ASA physical status I to III
- Age between 18 and 80 years old
- Scheduled for elective primary unilateral total knee arthroplasty with robotic surgery
- Able to speak and understand Cantonese, Mandarin, or English
- Able to provide informed oral and written consent
You will not qualify if you...
- Revision total knee arthroplasty
- Single-stage bilateral total knee arthroplasty
- Complex primary total knee arthroplasty requiring stem, augment, or constrained liner
- Surgeries with major complications affecting rehabilitation such as ligament injury or fracture requiring fixation
- Known allergy to opioids, local anesthetic drugs, paracetamol, or NSAIDs including COX-2 inhibitors
- History of chronic pain other than chronic knee pain
- History of immunosuppression or current use of immunosuppressants
- Chronic use of glucocorticoids
- Chronic opioid use
- History of congestive heart failure (NYHA class 2)
- Alcohol or drug abuse
- Impaired renal function (eGFR less than 30 ml/min/1.73m2)
- Impaired liver function (high bilirubin, INR ≥ 1.7, ALT or AST over 100 U/L)
- Blood clotting disorders or use of anticoagulants that prevent adductor canal block
- Pre-existing neurological or muscular disorders
- Psychiatric illness or impaired mental state
- Pregnancy
- Local infection
- Body mass index 40 or higher
- Refusal of regional nerve blocks or clinical trial participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 7 days after surgery
Participants receive an adductor canal block with one of three doses of bupivacaine to manage pain after total knee arthroplasty.
1 baseline visit and daily visits up to postoperative day 7
Follow-up
Duration - Up to 6 months after surgery
Participants are monitored for recovery, side effects, and pain outcomes after treatment.
Visits at 6 weeks, 3 months, and 6 months post-surgery
Trial Site Locations
Total: 1 location
1
The University of Hong Kong
Hong Kong, Hong Kong, Hong Kong
Actively Recruiting
Loading map...
Research Team
S
Stanley S.C. WONG, MD (HKU)
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Development and testing of a neuropathic pain screening questionnaire: ID Pain.
Russell Portenoy
https://pubmed.ncbi.nlm.nih.gov/16870080Psychometric testing of the Chinese quality of recovery score.
Matthew T V Chan, Charlotte C K Lo, Candy K W Lok...
https://pubmed.ncbi.nlm.nih.gov/18806027Is the SF-12 version 2 Health Survey a valid and equivalent substitute for the SF-36 version 2 Health Survey for the Chinese?
Elegance T P Lam, Cindy L K Lam, Daniel Y T Fong...
https://pubmed.ncbi.nlm.nih.gov/22128754Development and longitudinal validation of the overall benefit of analgesia score: a simple multi-dimensional quality assessment instrument.
N Lehmann, G P Joshi, D Dirkmann...
https://pubmed.ncbi.nlm.nih.gov/20693179A prospective, randomized trial of liposomal bupivacaine compared to conventional bupivacaine on pain control and postoperative opioid use in adults receiving adductor canal blocks for total knee arthroplasty.
Aurora Quaye, Brian McAllister, Joseph R Garcia...
https://pubmed.ncbi.nlm.nih.gov/38297390Liposomal Bupivacaine in Adductor Canal Blocks Before Total Knee Arthroplasty Leads to Improved Postoperative Outcomes: A Randomized Controlled Trial.
Ajith Malige, Anna N Pellegrino, Kelcei Kunkle...
https://pubmed.ncbi.nlm.nih.gov/35351553Liposomal Bupivacaine vs Ropivacaine for Adductor Canal Blocks in Total Knee Arthroplasty: A Prospective Randomized Trial.
Marc Hungerford, Philip Neubauer, Joseph Ciotola...
https://pubmed.ncbi.nlm.nih.gov/34556382Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty: A Randomized, Controlled Trial.
Collin P Hubler, Kristin M Bevil, Justin J Greiner...
https://pubmed.ncbi.nlm.nih.gov/34292820Adductor canal block combined with local infiltration analgesia versus isolated adductor canal block in reducing pain and opioid consumption after total knee arthroplasty: a systematic review and meta-analysis.
Jianyong Lv, Cuiyuan Huang, Zuofeng Wang...
https://pubmed.ncbi.nlm.nih.gov/32776794