Actively Recruiting
The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster
Led by Beijing Tiantan Hospital · Updated on 2026-01-30
750
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Recent attention has focused on the potential role of muscle relaxant, which can relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Therefore, investigators hypothesize that baclofen may effectively reduce the severity of HZ pain without significantly increasing adverse events.
CONDITIONS
Official Title
The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages more than 18 years
- Onset of herpes zoster rash less than 90 days
- Moderate to severe herpes zoster pain with an average pain score of at least 4 on a Numeric Rating Scale
- Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal
- Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher
- Ability and willingness to sign the informed consent form with sufficient cognitive and language skills to follow study requirements
You will not qualify if you...
- History of taking baclofen
- Evidence of cutaneous or visceral dissemination of herpes zoster infection or ocular involvement
- History of intolerance or hypersensitivity to baclofen or its components
- History of systemic immune diseases, organ transplantation, or cancers
- Pregnancy or breastfeeding
- Having acute or chronic pain disorders other than herpes zoster
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Beijing, Beijing 100070
Beijing, China
Actively Recruiting
Research Team
F
Fang Luo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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