Actively Recruiting
The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster
Led by Beijing Tiantan Hospital · Updated on 2026-01-30
750
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Topical NSAIDs offer a promising alternative by delivering localized analgesia with reduced systemic exposure. Therefore, investigators hypothesize that loxoprofen sodium patch may effectively reduce the severity of HZ pain without significantly increasing adverse events.
CONDITIONS
Official Title
The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Herpes zoster rash onset less than 90 days ago
- Moderate to severe herpes zoster pain with an average pain score of at least 4 on a Numeric Rating Scale
- Liver enzyme levels (AST and ALT) less than twice the upper limit of normal
- Estimated kidney function (eGFR) of 30 mL/min per 1.73 m2 or higher
- Ability and willingness to sign informed consent and comply with study requirements
You will not qualify if you...
- Previous use of loxoprofen sodium patch
- Evidence of widespread herpes zoster infection beyond adjacent skin areas or eye involvement
- Allergy or intolerance to loxoprofen sodium patch components
- History of systemic immune diseases, organ transplantation, or cancer
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Beijing, Beijing 100070
Beijing, China
Actively Recruiting
Research Team
F
Fang Luo
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here