Actively Recruiting
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations
Led by Institute of Cancer Research, United Kingdom · Updated on 2025-09-26
4260
Participants Needed
1
Research Sites
1108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
GENPROS aims to analyse the outcomes of patients with rare gene mutations in the cancer predisposition genes, BRCA1, BRCA2, HOXB13, and Lynch Syndrome, after a diagnosis of and treatment for prostate cancer (PCa). The study includes a cohort of gene mutation carriers with PCa matched with a control group of men with PCa who are known not to carry a mutation in the same gene. Clinical data regarding treatment and patient outcome will be collected retrospectively and prospectively. Archived tumour samples will also be collected for tumour profiling. A blood or saliva sample will be taken, if the participant consents to this part of the study, for genetic profiling to investigate any association of other inherited factors with PCa outcomes. Information obtained from this study will be of critical importance to support clinical trials investigating the most appropriate management of PCa in this group of patients at increased risk of prostate cancer.
CONDITIONS
Official Title
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men diagnosed with prostate cancer
- Known carriers of germline mutations associated with prostate cancer risk
- Known non-carriers of mutations in the specified genes
You will not qualify if you...
- Under 18 years of age
- Unable to give informed consent
- Cannot be traced or have less than 6 months follow-up
- Genetic status unknown
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Cancer Research and Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
E
Elizabeth C Page, MSc
CONTACT
E
Elizabeth Bancroft, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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