Study of Muscle Cell Energy and Structure Changes in the Quadriceps Before and After Endobronchial Valve Treatment for Severe Emphysema

What this Trial Is About

This research focuses on patients with severe emphysema undergoing bronchoscopic lung volume reduction treatment using one-way endobronchial valves EBV. Emphysema often leads to peripheral muscle dysfunction, which affects exercise ability, quality of life, and survival. The study aims to investigate how EBV treatment influences the physiological and structural function of skeletal muscles at the cellular level, an area not previously studied. Participants scheduled for EBV treatment will undergo advanced muscle testing using 31P-Magnetic Resonance Spectroscopy during exercise to measure muscle energy metabolism. Muscle biopsies will also be taken before and after the treatment to analyze muscle fiber types, mitochondrial density, and other markers related to muscle function. This is a single-arm study comparing muscle function before and after EBV treatment. During the study, participants will have muscle function measured through imaging and biopsies at baseline and again 6 months after EBV placement. The main outcomes include changes in quadriceps muscle phosphocreatine concentration and other biochemical markers of muscle energy use and structure. Safety and treatment effects will be monitored through these detailed assessments, with the total study period lasting about six months.

Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment