Actively Recruiting
Analysis of Biological Characteristics of Advanced ALK-rearranged NSCLC
Led by Groupe Francais De Pneumo-Cancerologie · Updated on 2026-04-29
100
Participants Needed
46
Research Sites
301 weeks
Total Duration
On this page
Sponsors
G
Groupe Francais De Pneumo-Cancerologie
Lead Sponsor
T
Takeda
Collaborating Sponsor
AI-Summary
What this Trial Is About
BioEXALK is a prospective study evaluating the biological characteristics of advanced ALK-rearranged NSCLC treated with next generation TKIs in first line, included in the national EXPLORE ALK cohort (GFPC 03-2019), a non-interventional, national, multi-center cohort of ALK-rearranged NSCLC patients. BioExALK study will be proposed to every patient included in the Explore ALK GFPC 03-2019 study. Biological analysis will be performed on tumor tissue at diagnosis and at the time of disease progression when available and on circulating tumor DNA (ctDNA). For plasma testing, after obtained patient consent, blood samples will be taken and analyzed at the Léon Bérard Center (Lyon). Biological analysis on tissue obtained at diagnosis and at disease progression will be collected and be sent for centralized analysis to the Rouen University Hospital.
CONDITIONS
Official Title
Analysis of Biological Characteristics of Advanced ALK-rearranged NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stage IIIB/IV non-small cell lung cancer not eligible for curative locoregional treatment
- ALK rearrangement confirmed by IHC, FISH, or NGS using local methods
- Patient included in the EXPLORE ALK study
- Age 18 years or older
- Treated with first-line new generation ALK inhibitor
- Patient agrees to sign informed consent and provide blood samples at inclusion, first tumor evaluation, and progression
- Tumor biopsy at diagnosis must be available
- Enrolled in the French National Health Insurance program or covered by a third-party payer
You will not qualify if you...
- Patients who do not wish to participate in BioEXALK
- Patients under guardianship
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 46 locations
1
Pneumologie CHU Félix Guyon
Saint-Denis, La Réunion, France, 97400
Actively Recruiting
2
Centre Hospitalier d'Aix en Provence
Aix-en-Provence, France, 13616
Not Yet Recruiting
3
Pneumologie CHU
Amiens, France, 80054
Not Yet Recruiting
4
Centre Hospitalier Universitaire
Angers, France, 49033
Not Yet Recruiting
5
Centre Hospitalier d'Annecy
Annecy, France, 74374
Actively Recruiting
6
Centre Hospitalier du Morvan
Brest, France, 29200
Actively Recruiting
7
Centre François Baclesse
Caen, France, 14000
Not Yet Recruiting
8
Pneumologie CH Métropole Savoie
Chambéry, France, 73000
Actively Recruiting
9
Oncologie CLCC Jean Perrin
Clermont-Ferrand, France, 63000
Not Yet Recruiting
10
Centre Hospitalier Intercommunal de Créteil
Créteil, France, 94010
Actively Recruiting
11
Pneumologie CH Eure-Seine
Évreux, France, 27000
Actively Recruiting
12
Pneumologie CHD Vendée
La Roche-sur-Yon, France, 85925
Actively Recruiting
13
Pneumologie Hôpital Mignot
Le Chesnay, France, 78157
Not Yet Recruiting
14
Pneumologie CH
Le Mans, France, 72000
Not Yet Recruiting
15
Oncologie Centre Oscar Lombret
Lille, France, 59000
Not Yet Recruiting
16
Pneumologie Hôpital Calmette
Lille, France, 59000
Not Yet Recruiting
17
Pneumologie CHU Limoges
Limoges, France, 87042
Not Yet Recruiting
18
Hôpital du Scorff
Lorient, France, 56100
Actively Recruiting
19
Pneumologie Hôpital privé Jean Mermoz
Lyon, France, 69085
Not Yet Recruiting
20
Centre Léon Bérard
Lyon, France, 69373
Actively Recruiting
21
Oncologie Hôpital François Quesnay
Mantes-la-Jolie, France, 78200
Not Yet Recruiting
22
Pneumologie Hôpital Européen
Marseille, France, 130003
Actively Recruiting
23
Oncologie Institut Paoli Calmette
Marseille, France, 13273
Not Yet Recruiting
24
Hôpital Nord
Marseille, France, 13915
Actively Recruiting
25
Hôpital de Meaux
Meaux, France, 77100
Actively Recruiting
26
Oncologie Institut du Cancer de Montpellier
Montpellier, France, 34298
Not Yet Recruiting
27
Oncologie CH Morlaix
Morlaix, France, 29600
Not Yet Recruiting
28
Pneumologie CHR
Orléans, France, 45000
Actively Recruiting
29
Oncologie Institut Curie
Paris, France, 75005
Not Yet Recruiting
30
Pneumologie Centre Hospitalier
Pau, France, 64000
Actively Recruiting
31
Hôpital du Haut Leveque
Pessac, France, 33604
Not Yet Recruiting
32
CHU Pontchailloux
Rennes, France, 35000
Actively Recruiting
33
Hôpital Charles Nicolle
Rouen, France, 76031
Actively Recruiting
34
Pneumologie Hôpital Yves Le Foll
Saint-Brieuc, France, 22000
Not Yet Recruiting
35
CHU La Réunion Site Sud
Saint-Pierre, France, 97410
Actively Recruiting
36
Institut Lucien Neuwirth
Saint-Priest-en-Jarez, France, 42271
Actively Recruiting
37
Centre Paul Strauss
Strasbourg, France, 67065
Not Yet Recruiting
38
Pneumologie Hôpital Foch
Suresnes, France, 92150
Actively Recruiting
39
Pneumologie HIA
Talence, France, 33400
Not Yet Recruiting
40
Pneumologie Hôpital Sainte Musse
Toulon, France, 83056
Not Yet Recruiting
41
Hôpital d'Instruction des Armées Ste Anne
Toulon, France, 83800
Actively Recruiting
42
Hôpital Larrey
Toulouse, France, 31059
Not Yet Recruiting
43
Oncologie CH Bretagne-Atlantique
Vannes, France, 56000
Actively Recruiting
44
Centre Hospitalier de Villefranche sur Saone
Villefranche-sur-Saône, France, 69655
Actively Recruiting
45
Oncologie Institut Gustave Roussy
Villejuif, France, 94805
Not Yet Recruiting
46
Pneumologie CHI
Villeneuve-Saint-Georges, France, 94195
Not Yet Recruiting
Research Team
F
Florian GUISIER
CONTACT
A
Aurélie SWALDUZ
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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