Actively Recruiting
Analysis of Circulating Tumor DNA Dynamics to Predict and Monitor Response to TKI in Patients With Advanced NSCLC.
Led by Gene Solutions · Updated on 2025-07-16
50
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational study, aiming to investigate whether the ctDNA dynamics analyzed by the K-TrackTM assay could predict early response to Tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC). 1. Determine relationship between ctDNA dynamics and clinical response to TKI, * No response/progressive disease = ctDNA levels increase from baseline * Partial response/stable disease = ctDNA levels decrease from baseline * Complete response = ctDNA clearance. 2. Compare and combine ctDNA dynamics and RECIST1.1 to predict clinical response. 3. Determine relationship between ctDNA dynamics and progression free survival, overall survival.
CONDITIONS
Official Title
Analysis of Circulating Tumor DNA Dynamics to Predict and Monitor Response to TKI in Patients With Advanced NSCLC.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with advanced non-small cell lung cancer and planned for first or second line TKI treatment; TKI combined with chemotherapy is allowed
- Available formalin-fixed paraffin-embedded (FFPE) or fine needle aspiration (FNA) tumor sample
- Able to comply with the treatment protocol
- Provided consent to participate in the study
You will not qualify if you...
- Already started Tyrosine kinase inhibitor treatment before enrollment
- Already started chemotherapy before enrollment
- Medical or psychiatric conditions or occupational responsibilities that may prevent following the protocol
- Did not agree to participate in the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical Genetics Institute
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
L
Lan NL Tu, PhD
CONTACT
V
VAN T Phan, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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