Study of Coronary Reactivity Testing Before and After Intracoronary Nitroglycerin in Adults with Angina Without Obstructive Coronary Artery Disease

What this Trial Is About

Researchers are evaluating coronary flow reserve CFR, index of microcirculatory resistance IMR, and related measurements in patients with angina but without significant coronary artery disease. This prospective, single-arm study involves patients undergoing coronary angiography for angina with non-obstructive coronary artery disease ANOCA or INOCA. The goal is to understand changes in these coronary function measures before and after intracoronary nitroglycerin administration. Participants will undergo coronary reactivity testing CRT in the left anterior descending and right coronary arteries. First, measurements such as CFR, IMR, distal coronary to aortic pressure ratio PdPa, transit times, resting full-cycle ratio RFR, fractional flow reserve FFR, and resistive reserve ratio RRR will be taken without intracoronary nitrates. Then, a dose of 200-500 mcg of intracoronary nitroglycerin will be administered and the same measurements repeated to observe changes. During the study, approximately 50 patients will be monitored during their cardiac catheterization procedure. Data will be collected intraoperatively to compare coronary function variables before and after nitrate administration. Researchers will analyze primary outcomes focusing on CFR changes and secondary outcomes including IMR, Pd, Pa, RRR, and transit times. The study aims to provide detailed insight into coronary microcirculatory function in this patient population.

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing