Actively Recruiting
Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
Led by University Hospital, Lille · Updated on 2025-12-26
40
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The pathophysiology of systemic sclerosis (SSc) is still poorly understood and there are no effective treatments for this disease. SSc is a heterogeneous disease with varying severity. The heterogeneity of fibroblast profiles, observed in other fibrosing pathologies, has never been thoroughly explored in the skin of SSc patients. The immune system, and in particular B lymphocytes, plays a central role in the pathophysiology of SSc. The interactions between B lymphocytes and the cells responsible for excess collagen production, i.e. fibroblasts, are not fully elucidated The main objective is to analyze the heterogeneity of fibroblasts and infiltrating immune cells as well as their molecular signature in the skin of patients with SSc
CONDITIONS
Official Title
Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Man or woman over 18 years of age
- Diagnosis of systemic sclerosis meeting the ACR-EULAR 2013 criteria
- Signed informed consent
- Being insured
You will not qualify if you...
- Overlap syndrome with another connective tissue disease according to international criteria
- Use of immunosuppressive treatment within the last 12 months
- Current corticosteroid therapy dose of 10 mg/day or higher
- Protected minors or adults
- Pregnant or breastfeeding women
- Deprived of liberty
- Persons in emergency situations
- Persons who have refused or are unable to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hop Claude Huriez Chu Lille
Lille, France, 59037
Actively Recruiting
Research Team
D
David Launay, MD,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here