Study of Skin Cells and Immune System in Adults with Systemic Sclerosis

What this Trial Is About

Systemic sclerosis SSc is a complex disease with varying severity and poorly understood causes. This research investigates the diversity of fibroblasts and immune cells in the skin of patients with SSc, focusing on their molecular characteristics. The role of B lymphocytes and their interaction with fibroblasts, which produce excess collagen, is a key part of this study, aiming to better understand disease mechanisms. Participants include patients who meet specific criteria for systemic sclerosis. The study involves collecting blood samples and skin biopsies from these participants. Both patients with SSc and healthy subjects are included to compare findings. This is an observational study that does not involve experimental treatments. Participants will undergo single-cell RNA sequencing analysis of their skin and blood samples at the time of inclusion. The study measures molecular signatures of cells to explore disease pathways. The total duration of participation is not specified, but the primary and secondary outcomes focus on detailed cellular analysis at enrollment. The study is sponsored by the University Hospital, Lille.

Analysis of Dermal Fibroblasts and Immune Cells During Systemic Sclerosis