Actively Recruiting
Analysis of DR Progression to Identify Risks and Need for Treatment
Led by Association for Innovation and Biomedical Research on Light and Image · Updated on 2026-03-02
1000
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
A
Association for Innovation and Biomedical Research on Light and Image
Lead Sponsor
F
Fundação para a Ciência e a Tecnologia
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to understand whether vascular and structural changes in the eyes caused by diabetes can help predict which people are more likely to experience worsening diabetic retinopathy (a diabetes-related eye disease) and how these eye changes are related to cardiovascular complications. The study will include about 1,000 people with type 2 diabetes, aged 35 to 90 years, and will take place over twelve months. It may also include a retrospective component, where existing medical and imaging data collected from previous visits (within the last 1 to 5 years) will be analyzed. The main questions it aims to answer are: * Can eye vessel and tissue changes, observed through modern imaging techniques and clinical data, help better describe and predict which cases of diabetic retinopathy will become more severe? * Can these same eye changes help predict the presence and risk of cardiovascular problems-such as heart disease or stroke-in people living with type 2 diabetes?
CONDITIONS
Official Title
Analysis of DR Progression to Identify Risks and Need for Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with type 2 diabetes according to the 1985 WHO criteria
- Age between 35 and 90 years
- For retrospective visits, documented follow-up of 1 to 5 years with at least one clinical visit
- For referenced patients, presence of diabetic retinopathy, at least one cardiovascular risk factor, or cardiovascular complications at baseline
- Signed informed consent
You will not qualify if you...
- Previous laser photocoagulation or intravitreal injections (consider corticosteroids)
- Clinically significant macular edema with vision loss or requiring immediate treatment
- Proliferative diabetic retinopathy
- Any ocular surgery within the previous 3 months
- Renal replacement therapy such as hemodialysis or peritoneal dialysis
- Severe systemic illness as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AIBILI-Clinical Trial Centre
Portugal, Coimbra District, Portugal, 3000-548
Actively Recruiting
Research Team
J
Joana F Tavares, PhD
CONTACT
L
Liliana C Soares, MsC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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