Surgical treatment of skeletal metastatic lesions of the proximal femur: endoprosthesis or reconstruction nail?
R Wedin, H C F Bauer
https://pubmed.ncbi.nlm.nih.gov/16326880Actively Recruiting
Age: 18Years +
All Genders
ID06918860
Complications, Implant Survival and Functional Results After Surgical Treatment of Bone Metastases of Proximal Femur With Intramedullary Nail or Prosthetic Reconstruction
Led by Costantino Errani · Updated on 2026-05-22
600
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are collecting and analyzing data from adult patients who underwent surgery for impending or pathological fractures of the proximal femur caused by bone metastases. This observational study focuses on treatments including intramedullary nail (IMN), total hip arthroplasty (THA), hemiarthroplasty (HHA), and their variations, performed between January 1, 2000, and December 31, 2023, at two medical centers. The study involves reviewing medical records, radiologic images, and histological data from approximately 600 patients. Researchers will examine the outcomes of surgical treatments such as IMN, THA, HHA, Mega, or MegaTHA to assess implant survival, complications, and functional results over an average follow-up period of one year. Participants' clinical and imaging data will be analyzed to evaluate implant durability, surgical complications at baseline, and functional performance after one year. This review will help understand the long-term results of these surgical procedures for bone metastases of the proximal femur. The study is observational and does not involve new treatments or interventions.
CONDITIONS
Brief Title
Analysis of Intramedullary Nail and Prosthetic Reconstruction After Surgical Treatment of Bone Metastases of Proximal Femur
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Male and female adult patients surgically treated between 01/01/2000 and 31/12/2023 in Rizzoli Orthopaedic Institute and in Massachusetts General Hospital.
- Age 18 years or older at the time of surgery
- Patients with impending or pathological fracture due to bone metastases of the proximal femur (head/neck, intertrochanteric, subtrochanteric area).
- Patients who underwent either intramedullary nail (IMN), total hip arthroplasty (THA), hemiarthroplasty (HHA), Mega, or MegaTHA.
- Patients with available clinical and imaging data.
You will not qualify if you...
- Patients with pathological or impending fracture of proximal femur due to primary bone tumor.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Retrospective from 2000 to 2023
Participants' clinical and imaging data from previous surgeries are reviewed and analyzed.
1 review session (remote or in-person)
Long-term Monitoring
Duration - Up to 1 year
Participants are observed for implant survival, complications, and functional outcomes following surgical treatment of bone metastases of the proximal femur.
1 baseline visit and follow-up visits over 1 year
Trial Site Locations
Total: 1 location
1
Irccs Istituto Ortopedico Rizzoli
Bologna, Emilia-Romagna, Italy, 40134
Actively Recruiting
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Research Team
C
Costantino Errani, MD
R
Roberta Laranga, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Treatment for long bone metastases based on a systematic literature review.
Costantino Errani, Andreas F Mavrogenis, Luca Cevolani...
https://pubmed.ncbi.nlm.nih.gov/27650452Factors associated with the decision of operative procedure for proximal femoral bone metastasis: Questionnaire survey to institutions participating the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group.
Nobuhito Araki, Hirokazu Chuman, Tomoya Matsunobu...
https://pubmed.ncbi.nlm.nih.gov/28629828