What is this study trying to find out about vision changes after FS-LASIK surgery?

This study aims to understand how the bacteria on the surface of the eye change before and after FS-LASIK surgery and how these changes relate to dry eye symptoms caused by the surgery. By studying these changes, researchers hope to find new treatment ideas and reduce dry eye complications after FS-LASIK surgery.

Who may be eligible for this refractive surgery study?

Adults aged 18 to 45 who have stable vision and good corrected far vision may be eligible. Participants should have no history of eye trauma or surgery and no serious eye diseases or systemic conditions like autoimmune disorders. Please review eligibility criteria for more details.

Is there any cost to participate in this refractive surgery clinical trial?

Study-related care, including all exams and tests, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel or related costs.

Actively Recruiting

Age: 18Years - 45Years

All Genders

Healthy Volunteers

ID06448468

Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis FS-LASIK

Led by Second Affiliated Hospital of Nanchang University · Updated on 2024-07-31

200

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying the changes in the ocular surface microbiota in patients who have undergone femtosecond laser-assisted in-situ keratomileusis FS-LASIK surgery. The study focuses on understanding how these microbiota changes relate to dry eye syndrome DES caused by FS-LASIK. By analyzing these changes, new treatment ideas for patients with FS-LASIK induced DES may be developed, and the incidence of this condition might be reduced. The study will include 160 postoperative patients divided into two groups those with dry eye and those without. Microbial samples from the conjunctival sac will be collected before and after surgery. The ocular surface microbiota changes will be analyzed using 16S rRNA sequencing technology to evaluate their impact on FS-LASIK induced DES. Participants will undergo dry eye examinations, conjunctival sac microbiota sampling, and corneal nerve condition assessments before the surgery and on postoperative day 90. Researchers will track these measurements to understand the relationship between microbiota changes and dry eye development after FS-LASIK. The total participation duration includes preoperative and 90 days postoperative evaluations to monitor outcomes and collect relevant data.

CONDITIONS

Brief Title

Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis (FS-LASIK)

Who Can Participate

Age: 18Years - 45Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age 18 years or older
Stable refractive index with less than 0.5D change in the past 2 years
Best corrected far vision (CDVA) of 1.0 or better
For postoperative dry eye patients: OSDI score of 13 or higher plus at least two of the following: tear film rupture time 10 seconds or less, Schirmer I test 10mm or less, corneal fluorescein staining with more than 5 spots

You will not qualify if you...

History of eye trauma or eye surgery
Suspected keratoconus
History of other eye diseases such as keratitis, edema, glaucoma, uveitis, retinal detachment, macular degeneration, cataracts, or amblyopia
Preoperative severe dry eye disease
Systemic diseases like hyperthyroidism or autoimmune disorders
Severe mental disorders such as anxiety or depression

Research Team

yifeng yu

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