Actively Recruiting
Analysis of Patients With Autosomal Dominant Polycystic Kidney Disease Focusing on Clinical and Genetic Data
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-06
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are collecting clinical and genetic data from patients diagnosed with Autosomal Dominant Polycystic Kidney Disease (ADPKD), focusing especially on those receiving specific treatments such as Tolvaptan or Octreotide. The study aims to analyze and compare clinical, laboratory, and imaging outcomes to better understand disease progression and treatment effects, particularly related to kidney function and cyst development. This observational research is conducted at the Integrated Renal Genetic Diseases Outpatient Clinic of the Sant'Orsola-Malpighi Polyclinic under the direction of Prof. La Manna. Participants will have their personal and family medical histories taken, and data will be gathered and updated through outpatient visits over time. The study pays close attention to the relationship between genetic variants and clinical outcomes, tracking kidney function markers like creatinine, eGFR, proteinuria, and urinary osmolarity. Imaging will be used to monitor changes in kidney cyst size and number, comparing patients on specific therapies versus those not receiving these treatments. Secondary objectives include monitoring cardiovascular health, urologic complications, liver involvement, and side effects related to the specific therapies, such as liver damage or symptoms from water loss or gastrointestinal issues. During the study, patients will undergo regular evaluations including clinical exams, laboratory tests, and imaging to assess kidney disease progression and treatment impact. Researchers will continuously update the database with these findings, focusing on kidney function decline and cyst growth as primary outcomes. Additional monitoring of blood pressure, heart and brain vessel conditions, urinary tract issues, and liver cysts will provide a comprehensive picture of disease effects. The study plans to follow participants for up to five years to build a detailed and ongoing data resource.
CONDITIONS
Brief Title
Analysis of Patients With Autosomal Dominant Polycystic Kidney
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of Autosomal Dominant Polycystic Kidney Disease (ADPKD) based on Unified Criteria of Pei
- Diagnosis using age-differentiated ultrasound criteria if positive family history
- Genetic confirmation recommended if diagnosis is unclear or impacts treatment/family planning
- Ability to provide informed written consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants are monitored over time to collect clinical, genetic, laboratory, and imaging data related to Autosomal Dominant Polycystic Kidney Disease, including disease progression, treatment effects, and associated complications.
Regular outpatient monitoring visits over the study period
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
G
Gaetano La Manna, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here