Actively Recruiting
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study
Led by University Hospital, Bonn · Updated on 2025-12-23
30
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to use the technique of microdialysis to analyse the intraarticular space of the knee joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing cement spacer over the entire period of the first hospitalization (usually 14 days) to closely monitor pharmacological and immunological aspects. In detail, antibiotic concentrations in the joint cavity and systemic circulation will be assessed according to reinfection rates, infection-free survival and fucntional outcome over a 12-month folluw-up period.
CONDITIONS
Official Title
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical indication for two-stage revision of knee periprosthetic joint infection
- Approval for surgery by the orthopedic and anesthesiologic department
- Age 18 years or older
- Written, informed consent after detailed patient information about the study and possible risks
You will not qualify if you...
- Known allergies to antibiotics gentamicin and vancomycin used within the spacer
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
Research Team
A
Alexander Franz, Dr. med., B. Sc.
CONTACT
J
Julika Behrens
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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