Actively Recruiting
Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
Led by Fox Chase Cancer Center · Updated on 2025-01-10
16
Participants Needed
1
Research Sites
418 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a comparative study using resected/ biopsied tumors samples collected from renal cell carcinoma and urothelial carcinoma patients who underwent surgical removal of lesions, followed by immune checkpoint blockade (ICB) treatment targting programmed cell death 1 (PD1) but developed new lesions later were also removed and stored in the biosample repository (BSR). The histology and genomic analysis of the pre-treatment and metastatic samples from the same patient would be used to find out the changes that may have lead to metastasis. Also, metastatic samples from ICB naive patients would be collected and compared with those from ICB treated patients to find out if the metastasis in treated patients was due to development of reistance.
CONDITIONS
Official Title
Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with renal cell carcinoma or urothelial carcinoma who received immune checkpoint blockade and had clinical benefit but later developed a single new or progressing lesion that was surgically removed
- Patients with renal cell carcinoma who had a metastasectomy but did not receive immune checkpoint blockade treatment (to serve as a comparison group)
- Patients with other tumor types meeting criteria may be included later
You will not qualify if you...
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, United States, 19111-2497
Actively Recruiting
Research Team
M
Matthew Zibelman, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here