Actively Recruiting
Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging
Led by Universidad Complutense de Madrid · Updated on 2026-04-22
24
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to validate laser speckle contrast imaging (LSCI) as a non-invasive method for measuring superficial gingival blood perfusion. Accurate assessment of vascularization is essential for understanding periodontal and peri-implant wound healing, yet current clinical methods are limited by subjective interpretation and low reproducibility. Repeated LSCI measurements will be performed in healthy gingival tissues and in tissues undergoing different mucogingival healing patterns, including primary and secondary intention healing. The study will also evaluate factors that may influence perfusion readings, such as angulation, retractors, mirror use, temperature, and heart rate. The primary objective is to determine the reproducibility of LSCI measurements and to support its use as a reliable tool for monitoring oral soft-tissue vascularization and healing.
CONDITIONS
Official Title
Analysis of the Reliability and Validity of Laser Speckle Contrast Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Non-smokers
- Good systemic health
- Good periodontal health
- No current systemic medication
- Good oral hygiene
- For the retrospective surgical component: availability of previously documented clinical records from closed mucogingival surgical wounds or open palatal donor-site wounds, with prior consent allowing use of documented clinical material for research
You will not qualify if you...
- Pregnancy
- Use of anti-inflammatory medication within 7 days before evaluation
- Oral treatment within 6 months before evaluation
- For the prospective healthy-gingiva component: any condition not compatible with good systemic or periodontal health
- For the retrospective surgical component: absence of adequate previously documented clinical records or absence of prior consent for research use of the documented material
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Complutense University of Madrid
Madrid, Madrid, Spain, 28040
Actively Recruiting
Research Team
M
Mariano Sanz Alonso, DMD, MD, PHD
CONTACT
M
Mercedes Lopez Duran, DMD, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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