Actively Recruiting
Anatomo-clinico-biological Profiles in Severe Nasal Polyps
Led by Poitiers University Hospital · Updated on 2024-06-10
200
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Nasal sinus polyposis is a chronic inflammatory condition affecting the nasal cavity and sinuses, leading to multiple bilateral polyps. This condition affects 2 to 4% of the general population and is challenging to manage because current treatments often fail or lead to symptom recurrence. Researchers are studying the anatomical, clinical, and biological profiles of patients with severe nasal polyps to better predict how patients will respond to surgery and biotherapy treatments. The study involves identifying anatomo-clinico-biological correlations by examining the anatomopathological profile, clinical features, and cytokine signatures of nasal polyps. These profiles aim to guide patient management, especially for those resistant to medical treatments and requiring first-time surgical treatment such as ethmoidectomy. The research assesses these factors to help predict treatment response, including to newer biologic therapies. Participants will undergo evaluations including anatomical profiling, symptom assessment using a visual analogue scale, quality of life measurement with the Sino-Nasal Outcome Test, biological profiling, and cytokine concentration analysis in serum. These assessments occur on a single day. The study monitors symptom severity, quality of life, and biological markers to understand treatment resistance. Participation involves a one-day visit for these detailed evaluations under medical supervision.
CONDITIONS
Brief Title
Anatomo-clinico-biological Profiles in Severe Nasal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 18 years or older
- Diagnosed with nasal sinus polyposis resistant to medical treatment
- Requiring first-time surgical treatment with ethmoidectomy
- Has signed the consent form
- Has health insurance coverage
You will not qualify if you...
- Current or past treatment with biotherapy
- Use of general corticosteroid therapy within 4 weeks before surgery
- Protected person status (legal protection)
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo first-time surgical treatment with ethmoidectomy and immediate post-operative care.
1 visit (in-person)
Duration - 1 day
Participants are evaluated for anatomical and biological profiles related to nasal sinus polyposis, including symptom assessment and quality of life evaluation.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Chu Poitiers
Poitiers, France
Actively Recruiting
Research Team
F
Florent Carsuzza, Dr
K
karine Garnier
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here