Actively Recruiting
Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
Led by University of California, San Diego · Updated on 2026-01-15
80
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.
CONDITIONS
Official Title
Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and be available for the full study duration
- Aged 18 to 35 years
- For transgender/non-binary group: plan to start testosterone therapy and history of regular menstrual cycles every 24-35 days before starting therapy
- For cisgender female group: regular menstrual cycles every 24-35 days
You will not qualify if you...
- Pregnant or breastfeeding within two months of study enrollment
- Incarcerated or institutionalized with cognitive impairment
- Hemoglobin less than 11 gm/dl at screening
- Weighing less than 110 pounds
- Body mass index less than 18 or greater than 35
- Current endocrine diseases including untreated thyroid problems, pituitary or adrenal disease, polycystic ovary syndrome, or androgen-producing tumors
- Diabetes or kidney, liver, or heart disease
- History of ovary or uterus removal surgery
- History of brain or pelvic surgery or radiation
- Currently taking medications affecting reproductive hormones such as contraceptives, androgens, estrogens, progestins, GnRH antagonists, insulinomimetics, or metformin
- Prior testosterone therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, San Diego
San Diego, California, United States, 92037
Actively Recruiting
Research Team
A
Antoni Duleba, MD
CONTACT
M
Marisa Hildebrand, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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