Actively Recruiting
Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
Led by Canadian Cancer Trials Group · Updated on 2026-04-14
710
Participants Needed
57
Research Sites
470 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
N
NRG Oncology
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation Therapy or SBRT) as effective as usual external radiation therapy given with a brachytherapy boost (which involves radiation sources inserted directly into the prostate)?
CONDITIONS
Official Title
Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed prostate adenocarcinoma diagnosed within the last 9 months
- Unfavorable risk prostate cancer per NCCN guidelines (unfavorable intermediate, high, or very high risk)
- ECOG performance status 0, 1, or 2
- Age 18 years or older
- Medically fit for brachytherapy
- Able and willing to complete quality of life questionnaires in English, French, or Spanish
- Consent provided according to local and regulatory requirements
- Accessible for treatment and follow-up
- Treatment to start within 12 weeks of enrollment
- Willing to take pregnancy prevention precautions during the study
- ADT allowed up to 30 days before enrollment
- 5-alpha reductase inhibitors allowed with PSA correction if used within 6 months
- No prior chemotherapy, PARPi, radioligand, or other investigational drugs for prostate cancer
- Prior or concurrent malignancies allowed if they do not interfere with safety or efficacy assessment
- Urinary function with International Prostate Symptom Score (IPSS) less than 20
- HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months
You will not qualify if you...
- Prior pelvic radiotherapy
- Contraindications to radical prostate radiotherapy such as connective tissue disease or inflammatory bowel disease
- Use of anticoagulation medication unsafe to discontinue for brachytherapy or prior/current bleeding disorders
- Previous steam vaporization, transurethral resection, prostatectomy, or ablative prostate therapies
- Prostate volume greater than 60cc before starting androgen deprivation therapy
- Anatomy preventing precise brachytherapy implant (e.g., arch interference, large median lobe)
- Evidence of castrate resistance defined as rising PSA above 3.0 ng/ml with testosterone below 3.0 nmol/l
- Presence of hip prosthesis (unilateral hip replacement allowed if dose constraints achievable)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 57 locations
1
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States, 94531
Actively Recruiting
2
Kaiser Permanente Dublin
Dublin, California, United States, 94568
Actively Recruiting
3
Kaiser Permanente-Fremont
Fremont, California, United States, 94538
Actively Recruiting
4
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, United States, 93720
Actively Recruiting
5
Kaiser Permanente-Fresno
Fresno, California, United States, 93720
Actively Recruiting
6
Kaiser Permanente-Modesto
Modesto, California, United States, 95356
Actively Recruiting
7
Kaiser Permanente Oakland-Broadway
Oakland, California, United States, 94611
Actively Recruiting
8
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
9
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, United States, 94063
Actively Recruiting
10
Kaiser Permanente-Richmond
Richmond, California, United States, 94801
Actively Recruiting
11
Rohnert Park Cancer Center
Rohnert Park, California, United States, 94928
Actively Recruiting
12
Kaiser Permanente-Roseville
Roseville, California, United States, 95661
Actively Recruiting
13
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, United States, 95678
Actively Recruiting
14
Kaiser Permanente Downtown Commons
Sacramento, California, United States, 95814
Actively Recruiting
15
Kaiser Permanente-South Sacramento
Sacramento, California, United States, 95823
Actively Recruiting
16
Kaiser Permanente-San Francisco
San Francisco, California, United States, 94115
Actively Recruiting
17
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, United States, 95119
Actively Recruiting
18
Kaiser Permanente San Leandro
San Leandro, California, United States, 94577
Actively Recruiting
19
Kaiser San Rafael-Gallinas
San Rafael, California, United States, 94903
Actively Recruiting
20
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, United States, 95051
Actively Recruiting
21
Kaiser Permanente-Santa Rosa
Santa Rosa, California, United States, 95403
Actively Recruiting
22
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, United States, 94080
Actively Recruiting
23
Kaiser Permanente-South San Francisco
South San Francisco, California, United States, 94080
Actively Recruiting
24
Kaiser Permanente-Stockton
Stockton, California, United States, 95210
Actively Recruiting
25
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, United States, 95688
Actively Recruiting
26
Kaiser Permanente-Vallejo
Vallejo, California, United States, 94589
Actively Recruiting
27
Kaiser Permanente-Walnut Creek
Walnut Creek, California, United States, 94596
Actively Recruiting
28
Memorial Hospital East
Shiloh, Illinois, United States, 62269
Actively Recruiting
29
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, United States, 63376
Actively Recruiting
30
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, United States, 63141
Actively Recruiting
31
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
32
Siteman Cancer Center-South County
St Louis, Missouri, United States, 63129
Actively Recruiting
33
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, United States, 63136
Actively Recruiting
34
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Actively Recruiting
35
Northwell Health/Center for Advanced Medicine
Lake Success, New York, United States, 11042
Actively Recruiting
36
Manhattan Eye Ear and Throat Hospital
New York, New York, United States, 10065
Actively Recruiting
37
Lenox Hill Hospital
New York, New York, United States, 10075
Actively Recruiting
38
Saint Vincent Hospital
Erie, Pennsylvania, United States, 16544
Actively Recruiting
39
Jefferson Hospital
Jefferson Hills, Pennsylvania, United States, 15025
Actively Recruiting
40
Forbes Hospital
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
41
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
42
West Penn Hospital
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
43
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, United States, 15090
Actively Recruiting
44
Bon Secours Saint Francis Medical Center
Midlothian, Virginia, United States, 23114
Actively Recruiting
45
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, Virginia, United States, 23230
Actively Recruiting
46
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
47
Doctor H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
48
Royal Victoria Regional Health Centre
Barrie, Ontario, Canada, L4M 6M2
Actively Recruiting
49
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
50
Waterloo Regional Health Network
Kitchener, Ontario, Canada, N2G 1G3
Actively Recruiting
51
London Regional Cancer Program
London, Ontario, Canada, N6A 4L6
Actively Recruiting
52
Trillium Health Partners - Credit Valley Hospital
Mississauga, Ontario, Canada, L5M 2N1
Actively Recruiting
53
Lakeridge Health Oshawa
Oshawa, Ontario, Canada, L1G 2B9
Actively Recruiting
54
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
55
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
56
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
57
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
Research Team
W
Wendy Parulekar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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