Feasibility Study of Anesthesia Effects on Survival in Brain Cancer Surgery for High-Grade Gliomas

What this Trial Is About

Brain cancer, particularly high-grade gliomas like Glioblastoma Multiforme GBM, is a significant cause of illness and death worldwide. This research focuses on evaluating how different types of anesthesia used during brain tumor surgery might affect cancer progression and patient survival. While surgery, chemotherapy, and radiotherapy are standard treatments, this study explores the potential influence of anesthetic drugs, an area not extensively studied before. The study is a feasibility trial to understand recruitment and protocol adherence, setting the stage for a larger future study. The study involves 40 patients undergoing elective craniotomy for suspected high-grade glioma. Participants are randomly assigned to one of two groups one receives total intravenous anesthesia using propofol and remifentanil, while the other receives volatile inhalational anesthesia with sevoflurane and remifentanil. Both groups follow standard fasting and monitoring guidelines, with anesthesia carefully adjusted to maintain specific depth and carbon dioxide levels. No nitrous oxide is used during anesthesia. Participants will be monitored for recruitment and retention rates, adherence to anesthesia protocols, overall survival, and progression-free survival over six months. The study includes regular clinical assessments and postoperative MRI scans to track tumor progression. Researchers will also observe any challenges in following the anesthesia protocols and participant follow-up. This information will help design a more extensive multicenter randomized trial in the future.

Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study