Actively Recruiting
Anesthesia sTrategy foR Organ Procurement In braiN dEath
Led by University Hospital, Grenoble · Updated on 2026-02-23
270
Participants Needed
1
Research Sites
184 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated by preserved spinal activity. Volatile anesthetics may blunt these reflexes, but their potential benefits in this context have never been investigated. This randomized trial evaluates the effects of volatile anesthesia (sevoflurane), opioid administration (sufentanil), or no anesthetic drugs on intraoperative hemodynamic stability during organ procurement in brain-dead donors. The primary outcome is the proportion of operative time within a predefined arterial blood pressure range.
CONDITIONS
Official Title
Anesthesia sTrategy foR Organ Procurement In braiN dEath
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult brain-dead donor confirmed according to French public health code
- Organ donation procedure planned with potential procurement of at least one intra-abdominal or intra-thoracic organ
- Scheduled transfer to operating room for organ procurement within 6 hours
- Next of kin informed and no opposition to research from them
You will not qualify if you...
- Age under 18 years
- Donation after circulatory death donors
- Use of extracorporeal circulation at time of death
- Hemodynamic instability defined by noradrenalin dose greater than 1 g/kg/min
- Allergy to opioid or volatile anesthetic agents
- Personal or family history of malignant hyperthermia or risk-related myopathy
- Expressed opposition to research during lifetime documented by next of kin
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU Grenoble Alpes
Grenoble, France
Actively Recruiting
Research Team
B
Benoit CHAMPIGNEULLE, MD, PhD
CONTACT
A
Anaïs ADOLLE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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