Actively Recruiting
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
Led by University General Hospital of Patras · Updated on 2025-09-18
150
Participants Needed
1
Research Sites
27 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus surgery (FESS) performed under controlled hypotension. Patients are randomly assigned to receive either total intravenous anesthesia with propofol-remifentanil, propofol-remifentanil with adjunct ketamine and magnesium, sevoflurane-remifentanil, or sevoflurane-remifentanil with adjunct ketamine and magnesium. Primary outcomes include serum biomarkers of neuronal injury (S100B and neuron-specific enolase, NSE) measured perioperatively, as well as surgical field visibility and intraoperative bleeding scores. Secondary outcomes include recovery profile and postoperative pain.
CONDITIONS
Official Title
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years old or older
- Scheduled for functional endoscopic sinus surgery (FESS) under general anesthesia
- Able to provide informed consent
You will not qualify if you...
- Emergency surgery
- American Society of Anesthesiologists (ASA) physical status IV or V
- Severe liver or kidney dysfunction
- Known allergy or contraindication to study drugs (propofol, remifentanil, ketamine, magnesium, sevoflurane)
- Pregnant or lactating women
- Unable or unwilling to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
University General Hospital of Patras
Pátrai, Achaia, Greece, 26504
Actively Recruiting
Research Team
S
Sotiria Rizopoulou, M.D.,M.Sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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