Actively Recruiting
ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
Led by University of Maryland St. Joseph Medical Center · Updated on 2025-12-22
100
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
Sponsors
U
University of Maryland St. Joseph Medical Center
Lead Sponsor
L
La Jolla Pharmaceutical Company
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to evaluate the use of Angiotensin II in patients with low blood pressure post-surgery. Your information will be collected for 28 days post the procedure and initiation of the study drug to assess for safety events and complications.
CONDITIONS
Official Title
ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years of age or older undergoing cardiac surgery requiring cardiopulmonary bypass
- Patients with vasodilation indicated by a mean arterial pressure below 65 mmHg that is non-transient
- Patients adequately treated with fluids to support blood volume
- Systemic Vascular Resistance index below 1970 dynes·sec/cm5/m2 to confirm vasodilation, or diagnosis made by critical care team if no pulmonary artery catheter is present
- Biventricular systolic function equal to or better than pre-surgery baseline or patients receiving concurrent treatment
You will not qualify if you...
- Bleeding causing hypotension, defined as requiring more than 4 units of red blood cell transfusion within 24 hours
- Patients currently on extracorporeal membrane oxygenation (ECMO)
- Patients with active endocarditis
- Patients on renal replacement therapy or with creatinine levels above 4 mg/dl within 2 weeks before surgery
- Patients with contraindications to Angiotensin II such as pregnancy, breastfeeding, active coronary ischemia, mesenteric ischemia, limb ischemia, or high potassium levels above 5.5 meq/L while receiving Angiotensin II
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Maryland St. Joseph Medical Center
Towson, Maryland, United States, 21204
Actively Recruiting
Research Team
A
Aja Janyavula
CONTACT
S
Sam Rudow
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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