Study of Angiography-Based Vessel Fractional Flow Reserve After PCI Assessing Impact on Clinical Outcomes and Angina in Coronary Syndrome Patients

What this Trial Is About

Researchers are studying patients with coronary artery disease undergoing percutaneous coronary intervention PCI to better understand the value of angiography-based vessel fractional flow reserve vFFR and its change u0394vFFR after PCI. This study focuses on how these measures relate to major adverse cardiovascular events MACE, residual angina, and quality of life in people with chronic coronary syndromes, non-ST-segment elevation acute coronary syndromes, or ST-segment elevation myocardial infarction. It is a prospective multicenter observational study led by the Medical University of Warsaw. The study uses angiography images taken during PCI to calculate vFFR with specialized software. Patients undergoing PCI will be followed over time, with assessments at 6, 12, and 24 months after the procedure. The research will analyze the association of post-PCI vFFR and u0394vFFR values with clinical outcomes, angina symptoms, and quality of life scores from the Seattle Angina Questionnaire SAQ and EuroQol 5-level 5-dimensional questionnaire EQ-5D-5L. Various patient subgroups will also be evaluated. Participants will have their coronary angiograms analyzed using a CAAS workstation. Researchers will collect data on adverse cardiovascular events such as death, myocardial infarction, and repeat vessel revascularization, along with patients angina symptoms and quality of life at several time points during the 2-year follow-up. The study aims to improve understanding of how post-PCI functional measures relate to patient health and outcomes over time.

Angio-based Final Functional Effect of PCI