Actively Recruiting
Angiogenic Factors in the Conservative Management of Gestational Hypertension
Led by Saint Thomas Hospital, Panama · Updated on 2025-08-26
150
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. One of the most controversial scenarios is gestational hypertension, a group of hypertensive disorders considered the mildest form of the pre-eclamptic spectrum, where current recommendations indicate termination of pregnancy at 37 weeks. However, the decision is based on outdated guidelines developed at a time when angiogenic factors were just beginning to be known. The purpose of the study is to use angiogenic factors as a guide to decide the most appropriate gestational age for termination of pregnancy in patients diagnosed with gestational hypertension.
CONDITIONS
Official Title
Angiogenic Factors in the Conservative Management of Gestational Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women between 24 and 40 weeks of gestation
- Diagnosis of Gestational Hypertension based on ACOG criteria
- sFlt-1/PlGF ratio equal to or below 33
You will not qualify if you...
- Multiple gestation
- Maternal vasculitis
- Previous cesarean section of three or more
- Neurological conditions
- Chronic renal disease
- Purpura
- Heart disease
- sFlt-1/PlGF ratio of 34 or more
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Santo Tomas
Panama City, Provincia de Panamá, Panama, 0834-1439
Actively Recruiting
Research Team
O
Osvaldo Reyes, MD
CONTACT
G
Gerado Cardenas, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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