Study of Angiotensin-1-7 Effects on Blood Vessel Function and Blood Pressure in Healthy Older Adults Ages 65 to 80

What this Trial Is About

Researchers are investigating how aging affects the risk of hypertension and cardiovascular disease, focusing on the role of the sympathetic nervous system and blood vessel function. The study explores whether angiotensin-1-7, a hormone that may protect the cardiovascular system, can reduce sympathetic nervous system activity, lower blood pressure, and improve blood vessel function in healthy older adults. This randomized, double-blind, placebo-controlled crossover study involves two outpatient visits where participants receive either intravenous angiotensin-1-7 or saline. The angiotensin-1-7 infusion is administered in escalating doses over about two hours, followed by a steady dose, while saline is given in a matching volume. Each visit lasts around four hours, with at least one week separating the two sessions. During the study visits, participants undergo continuous monitoring of blood pressure, heart rate, and muscle sympathetic nerve activity. Endothelial function is assessed, and blood samples and endothelial cells are collected before and after infusions. Researchers will measure changes in sympathetic nerve activity, blood vessel diameter, blood pressure, heart rate, and plasma catecholamines to evaluate the effects of angiotensin-1-7 in aging. The study is conducted at a medical center and includes a screening visit to determine eligibility.

Angiotensin-(1-7) Cardiovascular Effects in Aging