Actively Recruiting
Angiotensin Receptor Blockers in Aortic Stenosis
Led by Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Updated on 2024-12-20
144
Participants Needed
2
Research Sites
365 weeks
Total Duration
On this page
Sponsors
I
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Lead Sponsor
O
Odense University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is intended to investigate the effect of angiotensin receptor blockers (ARBs) on mild-to-moderate aortic stenosis.
CONDITIONS
Official Title
Angiotensin Receptor Blockers in Aortic Stenosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mild to moderate aortic stenosis defined by peak aortic jet velocity between 2.5 and less than 4 m/s
- Normal left ventricular ejection fraction of 50% or higher
- Systolic blood pressure greater than 110 mmHg
- Diastolic blood pressure greater than 70 mmHg
You will not qualify if you...
- More than mild aortic or mitral valve regurgitation or presence of mitral stenosis
- Current use or medical indication for renin-angiotensin system medications or Aliskiren
- Known allergy or intolerance to angiotensin II receptor blockers (ARBs)
- Diagnosis of Alzheimer’s disease, dementia, or known non-compliance with treatments
- Renal dysfunction with glomerular filtration rate below 30 ml/min/1.73m2
- Chronic high potassium levels (hyperkalemia)
- Diagnosed liver failure, cirrhosis, hepatitis, or history of liver impairment
- Newly diagnosed diabetes within the past 2 months or poorly controlled diabetes
- Existing obstructive coronary artery disease with severe angina or recent heart attack within 3 months
- Pregnant or breastfeeding women
- Inability to read, understand, or sign the research consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
CRIUCPQ
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
2
Odense University Hospital
Odense, Denmark
Actively Recruiting
Research Team
M
Marie-Annick Clavel, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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