Actively Recruiting
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Led by Vanderbilt University Medical Center · Updated on 2025-10-15
100
Participants Needed
1
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. The Investigators propose a study examining the physiologic effect of ansa cervicalis stimulation (ACS) alone and in combination with HNS during PSG and DISE.
CONDITIONS
Official Title
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Consenting adults with a body mass index (BMI) of 25 to 40 kg/m2
- Diagnosed obstructive sleep apnea with an apnea-hypopnea index (AHI) between 20 and 80 events per hour
- At least 80% of apnea events are obstructive in nature
You will not qualify if you...
- Chronic use of opiate medications, illicit drug use, or alcohol dependency
- Presence of other known sleep disorders such as central sleep apnea, periodic limb movements, or narcolepsy
- History or evidence of cardiopulmonary disease, liver, renal, immunodeficiency, neurodegenerative diseases, or adverse reactions to anesthesia
- Prior upper airway reconstructive surgery excluding tonsillectomy
- Having an implanted neurostimulation device such as a cardiac pacemaker or nerve stimulator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
K
Katie Hartley-Estes, RPSGT
CONTACT
N
Nicole L Jones, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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