Actively Recruiting
Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells
Led by The Methodist Hospital Research Institute · Updated on 2026-04-16
15
Participants Needed
1
Research Sites
205 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed as a prospective, open label, single arm pilot clinical study that will establish the safety and efficacy of a single injection of mesenchymal stromal cells in patients. Each subject will receive one intra-articular injection of autologous mesenchymal stromal cells derived from infrapatellar fat pad (FP-MSC) tissue samples collected from the subject during anterior cruciate ligament (ACL) reconstruction surgery.
CONDITIONS
Official Title
Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older scheduled for anterior cruciate ligament (ACL) reconstruction with bone-to-bone patellar tendon autograft
- Receiving post-surgery physical therapy at a Houston Methodist physical therapy clinic
You will not qualify if you...
- Under 18 years of age
- Prior surgery on affected knee
- Diabetes
- Root repair, inflammatory arthropathy, or any other procedure that cannot follow an accelerated physical therapy protocol or is deemed exclusionary by the principal investigator
- Unable to attend physical therapy at Houston Methodist
- Vulnerable populations
- Immunocompromised conditions such as cancer treatment or kidney failure
- Heart disease including systolic blood pressure over 180 mm Hg or heart failure
- Active infections
- Non-English-speaking patients
- Known metal implants or allergy to contrast agents
- Pregnancy or planning to become pregnant during the study
- Conditions with bleeding disorders, thrombus risk, or skin infections
- Any condition that compromises study data integrity or outcomes as judged by the primary investigator
- Other medical conditions contraindicating study participation such as ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, Ehlers-Danlos syndrome, osteoporosis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Madison Bowden
CONTACT
H
Haley Goble
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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