A comparison of regional versus general anesthesia for ambulatory anesthesia: a meta-analysis of randomized controlled trials.
Spencer S Liu, Wyndam M Strodtbeck, Jeffrey M Richman...
https://pubmed.ncbi.nlm.nih.gov/16301234/Actively Recruiting
Led by Hospital for Special Surgery, New York · Updated on 2025-10-06
60
Participants Needed
1
Research Sites
30 weeks
Total Duration
This research aims to compare two types of nerve blocks, the anterior femoral cutaneous nerve block AFCNB and the adductor canal block ACB, in children and adolescents aged 8 to 18 undergoing knee surgeries such as anterior cruciate ligament ACL and medial patellofemoral ligament MPFL reconstruction. The purpose is to gather preliminary information on postoperative function, opioid use, pain levels, sensory effects, and patient-reported outcomes to help design a larger future study. Participants will be randomly assigned to receive either AFCNB or ACB along with standard pain relief care. Each nerve block uses a combination of bupivacaine a local anesthetic and dexamethasone a corticosteroid, with dosing specific to each block type. The study includes two groups those undergoing ACL surgery and those undergoing MPFL surgery, with 30 subjects total in each group split evenly between the two nerve block types. During the study, participants will keep a daily diary recording pain medication use and pain scores. Follow-up will include surveys and questionnaires administered by phone and during office visits with surgeons. Researchers will assess motor strength, opioid consumption, pain levels at rest and with movement, sensory changes, and patient satisfaction up to six months after surgery. This monitoring aims to understand the effects and recovery outcomes associated with each nerve block technique.
CONDITIONS
Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees
M
Marko Popovic
A
Alex Sideris, PhD
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Hospital for Special Surgery, New York
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Adductor canal block | Anterior femoral cutaneous block |
|---|---|---|
| What it is | A single‑shot adductor canal nerve block using bupivacaine plus dexamethasone delivered around the adductor canal | A single‑shot anterior femoral cutaneous nerve block using bupivacaine plus dexamethasone delivered targeting the anterior femoral cutaneous nerve |
| Role in the trial | Investigational regional anesthesia method randomly assigned to some participants | Investigational regional anesthesia method randomly assigned to other participants |
| Primary use | To manage postoperative pain and preserve quadriceps function after pediatric ACL or MPFL reconstruction | To manage postoperative pain and preserve quadriceps function after pediatric ACL or MPFL reconstruction |
| How it is performed | Local anesthetic and steroid injected into the adductor canal region | Local anesthetic and steroid injected in the anterior femoral cutaneous nerve area |
| Evidence status | Adductor canal blocks preserve quadriceps strength better than femoral nerve blocks in similar surgeries, without compromising pain control | No existing evidence in pediatric ACL/MPFL reconstruction on effectiveness compared with other blocks |
| Important risks | Not established; safety evidence in pediatric regional anesthesia exists but not specific to this block type/se surgery | Not established; safety evidence in pediatric regional anesthesia exists but not specific to this block type/se surgery |
| Important limitations | Effectiveness and safety for this block in pediatric ACL/MPFL surgery is under investigation; current evidence is extrapolated or based on adult data | Effectiveness and safety for this block in pediatric ACL/MPFL surgery is under investigation; no direct evidence available |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive either the anterior femoral cutaneous nerve block (AFCNB) or adductor canal block (ACB) as part of their knee surgery anesthesia and analgesia.
1 visit (in-person surgical procedure)
Duration - Up to 6 months post-surgery
Participants maintain a diary to document daily pain medication use and pain scores, and complete follow-up surveys and questionnaires during office visits and telephone calls.
Multiple visits including office visits and telephone follow-ups at 2 weeks, 6 weeks, 3 months, and 6 months post-surgery
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/27627711/Hospital for Special Surgery, New York
Lead Sponsor