Actively Recruiting
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis: Multicenter Prospective Cohort Study
Led by University of British Columbia · Updated on 2024-05-09
489
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying different surgical methods for treating patients with symptomatic lumbar isthmic spondylolisthesis, a condition affecting the spine. The study compares anterior and posterior interbody fusion surgeries to determine which technique helps reduce leg pain the most. This research is important because doctors do not yet agree on the best surgical approach for this condition, and the study aims to clarify outcomes over time. The study involves two groups of patients who will receive either anterior or oblique interbody fusion surgery with various fixation methods, or posterior interbody fusion surgery using different surgical approaches. These surgeries involve placing devices like synthetic cages or bone grafts to stabilize the spine. The study will collect data over multiple years to assess the results of these surgical options. Participants will be monitored through regular follow-up visits at 1, 2, 5, and 10 years after surgery. Researchers will measure leg pain improvement using a numeric rating scale and track adverse events, reoperations, spinal alignment changes, and quality of life outcomes. The study also includes economic analyses to understand costs related to the surgeries and their effects on patient health and function.
CONDITIONS
Brief Title
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older (or who have reached the age of majority in the participating province)
- Require surgical treatment for a diagnosis of single-level lumbar isthmic spondylolisthesis, any grade, in the lumbar and lumbosacral spine
- Are able to communicate in English or French
- Anterior interbody fusion group defined as having had an anterior or oblique approach with synthetic cage insertion, interbody bone graft without cage, or plate-screw construct with or without posterior rod-screw construct
- Posterior interbody fusion group will have only posterior approach procedure
You will not qualify if you...
- Previous spinal surgery
- Specific pathology at level above and below, including degenerative anterolisthesis or pars defect above or below index level
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to hospital discharge
Participants undergo either anterior or posterior interbody fusion surgery to treat lumbar isthmic spondylolisthesis, followed by immediate post-operative care.
1 surgery visit and several in-hospital care visits
Duration - Up to 10 years
Participants are followed after surgery to monitor recovery, adverse events, and outcomes including pain and disability at multiple time points.
Visits at 3 months, 1 year, 2 years, 5 years, and 10 years
Trial Site Locations
Total: 1 location
1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V6H 1N1
Actively Recruiting
Research Team
C
Charlotte Dandurand
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Frequently Asked Questions
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