Actively Recruiting
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis
Led by University of British Columbia · Updated on 2024-05-09
489
Participants Needed
1
Research Sites
788 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently there is no consensus on the best surgical treatment of patients with symptomatic isthmic spondylolisthesis (IS). Clinical equipoise exists amongst experienced clinicians on the various surgical techniques available. This study will involve multiple phases to answer specific research questions comparing anterior and posterior interbody fusion in patients with lumbar isthmic spondylolisthesis. The primary end point will be 1-year proportions of patients reaching minimal clinically important difference (MCID) in terms of leg pain measured by NRS leg. The secondary endpoints will be predetermined moderate to severe AEs, reoperations for nonunion, symptomatic adjacent segment disease, radiological alignment correction and correlation with HRQOL as well as economic analysis at 1, 2, 5 and 10 years.
CONDITIONS
Official Title
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older (or who have reached the age of majority in the participating province)
- Require surgical treatment for a diagnosis of single-level lumbar isthmic spondylolisthesis, any grade, in the lumbar and lumbosacral spine
- Are able to communicate in English or French
- Anterior interbody fusion group defined as having had an anterior or oblique approach with synthetic cage insertion, interbody bone graft without cage, or plate-screw construct with or without posterior rod-screw construct
- Posterior interbody fusion group will have only posterior approach procedure
You will not qualify if you...
- Previous spinal surgery
- Specific pathology at level above and below including degenerative anterolisthesis
- Pars defect above or below the index level
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V6H 1N1
Actively Recruiting
Research Team
C
Charlotte Dandurand
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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