Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial

What this Trial Is About

Researchers are evaluating the antibacterial effects of Nano Calcium Hydroxide when used as an intracanal medication in primary endodontic treatment of permanent molars with apical periodontitis. This clinical trial compares the bacterial reduction capacity of a rapidly forming hydrogel loaded with Nano Calcium Hydroxide against both nano and conventional calcium hydroxide in paste form. The aim is to better understand which form can more effectively reduce bacteria in root canals of affected teeth. Participants will receive one of three treatments after complete cleaning and shaping of the root canals: Nano Calcium Hydroxide in hydrogel form, Nano Calcium Hydroxide in paste form, or conventional Calcium Hydroxide in paste form. The medication is placed into dry root canals and fills the canals up to the orifice level, left in place for one week. This randomized, double-blind trial compares these three approaches to assess their antibacterial potential. During the study, bacterial samples will be collected from the root canals before and seven days after medication placement to measure bacterial count. Participants will be monitored for pain intensity daily for three days after treatment, flare-ups until the next visit, and periapical healing will be evaluated radiographically six months after the root canal filling. The study involves healthy adults aged 21 to 49 with permanent molars showing signs of apical periodontitis, with a total participation timeline extending up to six months for follow-up assessments.

Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication