Actively Recruiting
Anti-cancer Neoantigen mRNA Vaccine to Treat Solid Tumors
Led by Second Affiliated Hospital of Guangzhou Medical University · Updated on 2024-06-26
30
Participants Needed
1
Research Sites
712 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The WES and RAN-seq will be performed to identify and verify neoantigens and appropriate mRNA sequences will be verified, manufactured and protected for vaccine production by multiple in vitro and in vivo studies. Clinical studies will be performed to test anti-cancer function of the mRNA vaccine for immunotherapy of human cancer patients. In this phase I study, the safety, tolerance, and preliminary efficacy of the mRNA vaccine immunotherapy on human cancers will firstly be evaluated.
CONDITIONS
Official Title
Anti-cancer Neoantigen mRNA Vaccine to Treat Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with advanced cancer
- Life expectancy greater than 12 weeks
- Adequate heart, lung, liver, kidney, and blood function
- Availability of high quality vaccine for human use
- Informed consent explained to, understood by, and signed by patient or guardian; patient or guardian given a copy of the consent
You will not qualify if you...
- Prior acceptance of gene therapy
- Severe viral infections such as hepatitis B, hepatitis C, or HIV
- Known HIV positivity
- Active infectious diseases related to bacteria, virus, or fungi
- Other severe diseases deemed inappropriate by investigators
- Pregnant or lactating women
- Receiving systemic steroid treatment at or above 0.5 mg prednisone equivalent per kg per day
- Other conditions deemed inappropriate by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Actively Recruiting
Research Team
Z
Zhenfeng Zhang, MD, PhD
CONTACT
B
Bingjia He, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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