Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.

What this Trial Is About

Researchers are evaluating the effects of anti-hypertensive treatment combined with individualized exercise training on blood pressure and vascular health in patients with hypertension. This randomized controlled trial aims to understand how these treatments impact vascular function and metabolism, helping to improve personalized medicine approaches for managing hypertension through sensitive vascular biomarkers. Participants will be randomly assigned to one of two groups. One group receives guideline-based anti-hypertensive therapy plus an individualized exercise program three times a week, including aerobic and resistance training tailored to each patient's fitness level, supported by regular contact with exercise physiologists and group sessions. The other group receives guideline-based anti-hypertensive therapy alongside general lifestyle advice such as salt reduction, increased physical activity, and stress management. Throughout the one-year study, including a six-month treatment period and a six-month follow-up, participants will attend outpatient visits every two months for blood pressure checks and assessments of large and small blood vessels. Researchers will measure retinal vessel diameters, blood pressure, microvascular endothelial function, arterial stiffness, physical fitness, metabolic profiles, and inflammation markers. These evaluations will help determine the vascular and metabolic effects of treatment and exercise interventions over time.

Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.