Study of Anti-inflammatory Nutrition Effects on Non-surgical Periodontal Treatment in Adults with Periodontitis

What this Trial Is About

Researchers are investigating the impact of anti-inflammatory nutrition on the success of non-surgical periodontal treatment in people with periodontitis who follow a pro-inflammatory diet. The study aims to assess changes in specific biomarkers found in gingival crevicular fluid and blood serum, as well as clinical periodontal health parameters. This observational study will include 100 adults aged 20 to 65 years who have periodontitis and a dietary inflammatory index greater than zero. Participants will be divided into four groups based on diet inflammatory scores and whether they receive anti-inflammatory nutrition education. All will undergo non-surgical periodontal treatment. Two groups Q3-1 and Q4-1 will receive both the periodontal treatment and nutrition education, while the other two groups Q3-2 and Q4-2 will receive only the periodontal treatment. Samples and measurements will be collected at baseline, 1.5 months, and 3 months after treatment to evaluate changes. Throughout the study, participants will have clinical periodontal assessments and provide gingival fluid and blood samples to measure levels of inflammatory and oxidative stress markers like interleukins, tumor necrosis factor, total oxidant and antioxidant status, and C-reactive protein. Researchers will track periodontal pocket depth and clinical attachment loss over time. The study will last about 3 months after treatment, with multiple follow-up visits to monitor changes and treatment outcomes.

Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy