Actively Recruiting

Age: 20Years - 65Years
All Genders
ID07287540

Effects of Anti-inflammatory Nutrition on Non-surgical Periodontal Therapy Outcomes in People With Periodontitis

Led by Recep Tayyip Erdogan University Training and Research Hospital · Updated on 2026-06-05

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

R

Recep Tayyip Erdogan University Training and Research Hospital

Lead Sponsor

R

Recep Tayyip Erdogan University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are evaluating how anti-inflammatory nutrition affects the results of non-surgical periodontal treatment in people with periodontitis. The study focuses on measuring changes in gingival crevicular fluid and blood markers related to inflammation, as well as clinical signs of periodontal health. This research aims to understand whether anti-inflammatory dietary education can reduce gum inflammation and improve treatment outcomes. The study involves 100 volunteers with a pro-inflammatory diet, divided into four groups based on diet inflammation level and whether they receive anti-inflammatory nutrition education. All participants receive non-surgical periodontal treatment. Two groups with moderate and high pro-inflammatory diets will receive additional education about anti-inflammatory nutrition. Samples and clinical measurements will be taken at the start, 1.5 months, and 3 months after treatment to assess various inflammatory markers and periodontal health. Participants will undergo periodontal exams and provide gingival fluid and blood samples three times during the study. Researchers will measure pocket depth, attachment loss, and levels of inflammatory proteins such as interleukins, tumor necrosis factor, and C-reactive protein. Dietary inflammation scores will also be recorded. The study will monitor changes over three months to evaluate the effects of nutrition education combined with periodontal care. The total participation duration is about three months after initial treatment.

CONDITIONS

Brief Title

Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy

Who Can Participate

Age: 20Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Being systemically healthy
  • Not smoking
  • Not using anti-inflammatory drugs in the last 3 months
  • Not using antibiotics or systemic corticosteroids in the last 6 months
  • Not being pregnant or lactating
  • Not having received periodontal treatment in the last 6 months
  • Having at least 20 teeth in the mouth
  • Diagnosed with periodontitis by the investigator
  • Having a dietary inflammatory index greater than 0
Not Eligible

You will not qualify if you...

  • Having a systemic disease
  • Smoking
  • Using anti-inflammatory drugs within the last 3 months
  • Using antibiotics or systemic corticosteroids within the last 6 months
  • Being pregnant or lactating
  • Having received periodontal treatment within the last 6 months
  • Having fewer than 20 teeth in the mouth
  • Not having periodontitis

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Non-surgical Periodontal Treatment

Duration - 3 months

Participants receive nonsurgical periodontal treatment to manage periodontitis.

Visits at baseline, 1.5 months, and 3 months

Anti-inflammatory Nutrition Education

Duration - 3 months

Participants in certain groups receive education on anti-inflammatory nutrition alongside periodontal treatment.

Education sessions concurrent with treatment visits

Post-treatment Monitoring

Duration - Up to 3 months following treatment

Participants are monitored for changes in periodontal health and inflammatory markers after treatment.

Follow-up assessments at 1.5 and 3 months after treatment start

Trial Site Locations

Total: 1 location

1

Recep Tayyip Erdoğan University

Rize, Turkey (Türkiye), 53020

Actively Recruiting

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Research Team

H

Hatice Yemenoglu

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

4

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