Actively Recruiting
Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)
Led by Midwest Veterans' Biomedical Research Foundation · Updated on 2026-02-27
36
Participants Needed
1
Research Sites
267 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This will be a randomized clinical trial examining the efficacy and safety of ARAT (intervention group) in patients with chronic GERD symptoms (typical symptoms of GERD, i.e. heartburn or acid reflux/regurgitation at least twice a week) for the last 6 months. Patients must have a positive pH test and a negative manometry (no treatment) procedure.
CONDITIONS
Official Title
Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic GERD symptoms with typical symptoms (heartburn or acid reflux/regurgitation) at least twice a week for the last 6 months
- Positive ambulatory pH study confirming reflux disease
- Age between 18 and 80 years
You will not qualify if you...
- Unable or unwilling to participate or provide consent
- Age under 18 years or over 80 years
- Allergy or intolerance to proton pump inhibitor medications
- Large hiatal hernia greater than 3 cm and Hill grade IV
- Presence of Barrett's esophagus
- Esophageal stricture with any prior intervention
- Major esophageal motility disorder
- Eosinophilic esophagitis
- Documented gastroparesis with abnormal gastric emptying time
- Previous fundoplication, myotomy, or LINX surgery
- Cirrhosis with esophageal and/or gastric varices
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kansas City VA Hospital
Kansas City, Missouri, United States, 64128
Actively Recruiting
Research Team
A
April Higbee, BSN
CONTACT
C
Carlissa Campbell, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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