Antibiotic Concentrations After MassivE Transfusion (ACME) Study

What this Trial Is About

This research aims to understand how the volume of blood transfusions affects antibiotic levels in patients with open wounds due to trauma. It addresses a common problem where many combat and civilian trauma patients receive blood transfusions, but it is unclear how these transfusions change antibiotic concentrations used to prevent infections in wounds. The study will develop data-driven dosing models based on the relationship between blood transfusions and antibiotic levels. Participants include trauma patients who receive antibiotics such as ampicillin/sulbactam, cefazolin, and others during hospitalization. They are grouped into those receiving minimal or no blood transfusions (up to 2 units) and those receiving massive transfusions (at least 3 units). Blood samples are collected at six set timepoints after antibiotic administration, often using routine clinical blood draws with limited extra sampling. During the study, blood samples are processed and analyzed to measure antibiotic concentrations. Researchers will examine how transfused blood volume influences these levels using statistical models and data collected over time up to 30 days post-enrollment. The study ensures participant data privacy under HIPAA and involves minimal additional risks, qualifying for a waiver of informed consent. The total monitoring period extends up to 30 days after enrollment with ongoing data analysis.

Antibiotic Concentrations After MassivE Transfusion Study