Actively Recruiting
Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota
Led by Peking University People's Hospital · Updated on 2024-07-24
450
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how antibiotic exposure during pregnancy affects the gut microbiota and its development in newborns and infants up to 12 months old. This observational project collects biological samples from pregnant women and their babies to understand how antibiotics impact the diversity and function of gut bacteria early in life. The goal is to reveal how antibiotic use influences the growth and development of the infant's gut microbiome. Participants include pregnant women aged 20 to 40 years with natural conception and single pregnancies at 36 weeks or more gestation, along with their newborns who have normal Apgar scores and no serious congenital diseases. The study compares groups with antibiotic treatment during pregnancy, prophylactic antibiotic use, and natural delivery without antibiotics. Samples are collected at multiple time points during pregnancy (12, 24, and 37 weeks) and from newborns at birth, 1 week, and 1, 3, 6, and 12 months. During the study, researchers collect biological specimens to analyze the infant gut microbiome and antibiotic exposure over time. The main outcome is measuring the gut microbiome composition at specified intervals from pregnancy through the first year of life. This project includes healthy volunteers and tracks how antibiotic use during pregnancy may influence infant gut health and development, with participation lasting through the infant's first year.
CONDITIONS
Brief Title
Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant woman aged 20 to 40 years old
- Natural conception
- Single pregnancy
- Gestational age of 36 weeks or more
- Newborn with normal Apgar score
- No serious congenital diseases in newborn
You will not qualify if you...
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From 12 weeks of pregnancy through 12 months after birth
Participants are observed during pregnancy and infants are followed to study the effects of antibiotic exposure on infant gut microbiota.
Visits at 12, 24, and 37 weeks of pregnancy and at birth, 1 week, 1, 3, 6, and 12 months of infant age
Trial Site Locations
Total: 1 location
1
The Peking University People's Hospital
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here