Study of Antibiotic Irrigation Versus Saline for Drains in Abdominal Abscess Treatment

What this Trial Is About

This trial investigates treatment approaches for people with intra-abdominal abscesses, which are collections of pus inside the abdominal cavity. The study evaluates the clinical effects of irrigating the abscess drain with a higher local concentration of antibiotics compared to the standard practice of using normal saline. This research is conducted as a Phase 2 randomized trial to better understand how local antibiotic irrigation might impact recovery. Participants will be randomly assigned to one of two groups. One group will have their surgical drains irrigated twice daily with an antibiotic solution containing Gentamicin andor Clindamycin for up to 7 days or until the drain is removed. The other group will receive drain irrigation twice daily with normal saline as a placebo. The antibiotic dosages are specified as 5 mg Gentamicin in 10 ml volume twice daily and 12 mg Clindamycin in 10 ml once daily. Throughout the study and up to one month after starting systemic antibiotic treatment, researchers will monitor several outcomes including the duration of systemic antibiotic use, white blood cell count, body temperature changes, abscess size, drain output, and how long the drain remains in place. Participants will receive standard systemic antibiotics and will be followed during hospitalization and after discharge to assess these measurements.

Antibiotic Irrigations for Intra-Abdominal Drains