Prophylactic Antibiotics During Treatment of Idiopathic Overactive Bladder With Intradetrusor OnabotulinumtoxinA for Reduction of Postoperative UTI: A Randomized Blinded Placebo-Controlled Trial

What this Trial Is About

Researchers are studying whether giving antibiotics at the time of bladder Botox injection can reduce the chance of bladder infections afterward in women with idiopathic overactive bladder. The study focuses on women aged 18 and older who have not responded to medical treatments and are receiving Botox injections to help manage their symptoms. The goal is to see if taking antibiotics after the procedure prevents urinary tract infections and to check for any side effects linked to antibiotic use. Participants will be randomly assigned to one of two groups: one receiving the antibiotic Ciprofloxacin and the other receiving placebo pills. Both groups will take their assigned pills twice daily for three days after the Botox procedure. The Botox injection technique and dose, usually between 100 and 200 units across 10 to 20 sites in the bladder, will be determined by the doctor. This trial is double-blinded, meaning neither the patients nor the doctors will know who receives antibiotics or placebo. During the six weeks following the procedure, participants will have regular follow-up visits where questionnaires will assess symptoms of urinary tract infection, voiding issues, and any side effects. Urine cultures will be taken before the procedure and if infection symptoms appear postoperatively to confirm infections. The primary outcome is the rate of urinary tract infections two weeks after treatment, with additional monitoring at one and six weeks. The study also tracks other adverse events potentially related to the antibiotic use.

Antibiotic Prophylaxis for Bladder Botox