Study of Preventive Antibiotics After Botox Treatment for Neurogenic Overactive Bladder to Lower Postoperative Urinary Tract Infection Risk

What this Trial Is About

Researchers are evaluating the use of preventative antibiotics to reduce the risk of bladder infection after Botox injections for neurogenic overactive bladder. This condition occurs in people with neurological disorders like multiple sclerosis, Parkinsons disease, spinal cord injury, or stroke. The trial aims to determine whether giving antibiotics at the time of Botox treatment lowers the rate of postoperative urinary tract infections. This is a randomized, double-blinded study led by the University of Alberta, providing training opportunities for new researchers. Participants will be randomly assigned to receive either ciprofloxacin, an antibiotic, or a placebo pill twice daily for three days after the bladder Botox procedure. The Botox injection technique usually involves a trigone-sparing method with 200 units spread across 10 to 20 sites, but the exact method is at the physicians discretion. A urine culture is taken before the procedure to check for existing infections. During the six weeks after treatment, patients will have regular follow-ups where questionnaires will screen for urinary infection symptoms, voiding issues, or other side effects possibly related to antibiotics. Urine cultures will confirm infections if symptoms appear. The main outcome measured is the rate of urinary tract infections two weeks after the procedure, with additional assessments at one and six weeks. The study also monitors other adverse events during this time.

Antibiotic Prophylaxis for Neurogenic Bladder Botox