Actively Recruiting
An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care
Led by University Hospital, Caen · Updated on 2025-07-24
64
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Investigators propose to conduct a multicenter, prospective, randomized, controlled, assessing the interests of an antibiotic protocol guided by the combined use of serum procalcitonin (PCT) and a broad-panel respiratory multiplex PCR (mPCR) to reduce duration of antibiotics exposure in patients with chronic obstructive pulmonary disease (COPD) hospitalized in intensive care unit (ICU) with pneumonia. The primary endpoint is the number of antibiotic-days for the treatment of pneumonia.
CONDITIONS
Official Title
An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years
- Documented or suspected COPD according to GOLD criteria
- Community-acquired pneumonia confirmed by chest X-ray or CT scan with symptoms such as dyspnea, cough, sputum, fever above 38 °C, chest pain, localized crackles, or abnormal white blood cell counts
- Hospital admission less than 48 hours before ICU admission
- Admission to intensive care unit (ICU)
- Signed informed consent by patient or representative
You will not qualify if you...
- Immunocompromised patients including congenital immunodeficiency, blood cancers, immunosuppressive drugs (anticancer chemotherapy, post-transplant therapies), neutropenia with neutrophil count below 500/mm³ due to chemotherapy, corticosteroids over 0.5 mg/kg/day for more than 10 days, or HIV infection
- Patients with therapeutic limitations
- Minors or individuals under guardianship or custody
- Pregnant women
- Patients who refuse to participate
- Participation in another biomedical research protocol ongoing or within the last 30 days
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical Intensive Care Unit, CHU Caen
Caen, France, 14000
Actively Recruiting
Research Team
C
cedric daubin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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