Actively Recruiting
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Led by Case Comprehensive Cancer Center · Updated on 2026-03-05
30
Participants Needed
1
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
CONDITIONS
Official Title
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed squamous cell carcinoma of the oral cavity
- Planned surgery for curative intent
- 18 years of age or older
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- Known allergy to metronidazole or chlorhexidine
- Severe liver or kidney disease based on medical history or lab tests
- Actively drinking alcohol and unable to abstain during the 10-day antibiotic period
- Recurrent oral cancer after prior radiation or chemoradiation
- Unresectable oral cancer
- Unable to tolerate oral rinse or metronidazole by mouth or feeding tube
- Use of other antibiotics within 30 days prior to the study
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Case Comprehensive Cancer Center, Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
N
Natalie Silver, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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