Actively Recruiting
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Led by University of Geneva, Switzerland · Updated on 2026-04-29
45
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
Sponsors
U
University of Geneva, Switzerland
Lead Sponsor
U
University of Lausanne
Collaborating Sponsor
AI-Summary
What this Trial Is About
Periodontitits is a bacteria induced inflammatory disease that destroys the supporting tissues of the tooth and leads to tooth loss. Treatment consists mainly of the mechanical cleaning of the tooth surfaces in order to remove the bacterial deposits (plaque and calculus). This procedure can reduce the level of pathogenic bacteria but it can not eradicate them. In severe cases, for the complete resolution of the disease, the elimantion of certain species of bacteria is needed. In order to achieve that, the combination of different regimens of antibiotics adjunctive to the mechanical treatment has been proposed. However, dosage and duration of antimicrobial therapy should be optimal and not excessive as issues may arise related to increased antimicrobial resistance in the population and the individual due to habitual prescription of wide-spectrum antibiotic regimens, horizontal gene transfer and genetic mutation. In the present study, in an effort to optimize the dosage and duration of the antimicrobial regimen, we will determine the pharmacokinetics (PK) and pharmacodynamic (PD) properties of the MET-AMO combination and of AZI in Gingival Crevicular Fluid (GCF), saliva and serum in severe periodontitis patients during and after either a 3-day or a 7-day course of treatment.
CONDITIONS
Official Title
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Age between 18 and 80 years old
- Need for periodontal treatment with adjunctive antibiotic therapy
- At least 30% of teeth with probing depth greater than 6 mm and bleeding on probing
You will not qualify if you...
- Having systemic illnesses such as uncontrolled diabetes, cancer, HIV, bone metabolic diseases, or conditions impairing wound healing
- Pregnancy or lactation
- Antibiotic use within the previous 2 months
- Current use of nonsteroidal anti-inflammatory drugs
- Known or suspected allergy to 5-nitroimidazole derivatives, amoxicillin, or macrolides
- Periodontal therapy within the last year
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to participate due to language, psychological, or cognitive issues
- Unwillingness to attend regular dental visits and follow-up
- Participation in another investigational drug study within 30 days before or during this study
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Geneva, University Clinics of Dental Medicine
Geneva, Canton of Geneva, Switzerland, 1205
Actively Recruiting
Research Team
C
Catherine Giannopoulou, Dr med dent
CONTACT
A
Alkisti Zekeridou, Dr med dent
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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