Actively Recruiting
Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection
Led by Mount Sinai Hospital, Canada · Updated on 2024-09-19
550
Participants Needed
7
Research Sites
171 weeks
Total Duration
On this page
Sponsors
M
Mount Sinai Hospital, Canada
Lead Sponsor
S
Sault Area Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Delirium is an acute confusional state that is experienced by many older adults who are admitted to hospital. To treat delirium the underlying cause needs to be identified promptly, but this is challenging. One of the potential causes of delirium is infection. Urine tests show that most patients experiencing delirium have bacteria in their urine, however, bacteria in the urine is common among older adults, and does not automatically indicate an infection is present. As a result it is difficult to know whether a lower urinary tract infection is present as individuals with delirium are frequently unable to report clinical signs of infection - symptoms of pain or discomfort with urination, having to urinate more frequently or pelvic discomfort. Very often, individuals with delirium are treated with antibiotics despite the fact that it is unknown whether antibiotics help to improve delirium in cases where bacteria in the urine is present. This proposed study is a randomized controlled trial that will examine if adults (age 60 or older) with delirium and suspected infection benefit from taking antibiotics.
CONDITIONS
Official Title
Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older and admitted to a hospital ward, including rehabilitation hospital
- Active delirium defined by specific clinical criteria or physician's diagnosis
- Less than 24 hours of antibiotics use before trial assessment
- Presence of pyuria (white blood cells in urine) or bacteriuria (bacteria in urine culture)
You will not qualify if you...
- Fever over 37.9°C (100.2°F) in the past 48 hours
- Symptoms of lower urinary tract infection or upper urinary symptoms
- Physician believes antibiotics are needed for reasons other than delirium and urine test results
- Indwelling urinary catheter in place for more than 72 hours
- Received a single-dose antibiotic that suffices for urinary tract infection treatment (e.g., Fosfomycin)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Not Yet Recruiting
2
The Ottawa Hospital Civic Campus
Ottawa, Canada
Not Yet Recruiting
3
The Ottawa Hospital General Campus
Ottawa, Canada
Not Yet Recruiting
4
Hennick Bridgepoint Hospital
Toronto, Canada
Not Yet Recruiting
5
Michael Garron Hospital
Toronto, Canada
Actively Recruiting
6
Mount Sinai Hospital
Toronto, Canada
Actively Recruiting
7
Toronto General Hospital
Toronto, Canada
Not Yet Recruiting
Research Team
M
Michael Fralick, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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