Actively Recruiting
Antibody-mediated NMDA Receptor Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Prolonged Recovery Stage
Led by Fundacion Clinic per a la Recerca Biomédica · Updated on 2024-05-06
20
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
Sponsors
F
Fundacion Clinic per a la Recerca Biomédica
Lead Sponsor
H
Hospital Sant Joan de Deu
Collaborating Sponsor
AI-Summary
What this Trial Is About
The encephalitis mediated by antibodies against the NMDA receptor (NMDARe) predominantly affects young adults and children resulting in severe neurologic and psychiatric deficits. After overcoming the acute stage, patients are left with long-lasting behavioral, cognitive, and psychiatric alterations with important socio-family-economical implications. Here investigators postulate that a better knowledge of this stage will improve treatment decisions and outcome. In Aim 1, the post-acute stage will be clinically characterized, tools to remotely follow cognitive, behavioral and psychiatric deficits will be provided, and the impact of cognitive rehabilitation will be assessed. In Aim 2, biomarkers (autoimmune, inflammatory, neuronal injury) will be identified as signatures of the acute and post-acute stages. In Aim 3, a mouse model of NMDARe will be used to determine the underlying mechanisms and treatment of the postacute stage.
CONDITIONS
Official Title
Antibody-mediated NMDA Receptor Encephalitis: Symptoms, Biomarkers, and Mechanisms of the Prolonged Recovery Stage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 12 years old or older with NMDA Receptor Encephalitis in the post-acute stage of the disease
- Six months or less since hospital discharge from the acute phase
You will not qualify if you...
- Unable to provide informed consent
- Unable to travel to the study center
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Clínic de Barcelona
Barcelona, Catalonia, Spain, 08036
Actively Recruiting
Research Team
J
Josep Dalmau, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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